Evidence of multiple introductions and autochthonous transmission of the HIV type 1 CRF02_AG clade in Brazil.
Identifieur interne : 000728 ( Main/Exploration ); précédent : 000727; suivant : 000729Evidence of multiple introductions and autochthonous transmission of the HIV type 1 CRF02_AG clade in Brazil.
Auteurs : Edson Oliveira Delatorre [Brésil] ; Gonzalo Bello ; Walter A. Eyer-Silva ; Saada L. Chequer-Fernandez ; Mariza G. Morgado ; José Carlos Couto-FernandezSource :
- AIDS research and human retroviruses [ 1931-8405 ] ; 2012.
Descripteurs français
- KwdFr :
- ADN viral (génétique), Adulte, Analyse de regroupements, Brésil (épidémiologie), Données de séquences moléculaires, Femelle, Gènes pol (génétique), Génotype, Humains, Mâle, Phylogénie, Prévalence, Recombinaison génétique, Surveillance sentinelle, Séquence nucléotidique, Séropositivité VIH (transmission), Séropositivité VIH (virologie), Séropositivité VIH (épidémiologie), VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (génétique), Variation génétique.
- MESH :
- génétique : ADN viral, Gènes pol, VIH-1 (Virus de l'Immunodéficience Humaine de type 1).
- virologie : Séropositivité VIH.
- épidémiologie : Brésil, Séropositivité VIH.
- Adulte, Analyse de regroupements, Données de séquences moléculaires, Femelle, Génotype, Humains, Mâle, Phylogénie, Prévalence, Recombinaison génétique, Surveillance sentinelle, Séquence nucléotidique, Variation génétique.
- Wicri :
- geographic : Brésil.
English descriptors
- KwdEn :
- Adult, Base Sequence, Brazil (epidemiology), Cluster Analysis, DNA, Viral (genetics), Female, Genes, pol (genetics), Genetic Variation, Genotype, HIV Seropositivity (epidemiology), HIV Seropositivity (transmission), HIV Seropositivity (virology), HIV-1 (genetics), Humans, Male, Molecular Sequence Data, Phylogeny, Prevalence, Recombination, Genetic, Sentinel Surveillance.
- MESH :
- chemical , genetics : DNA, Viral.
- geographic , epidemiology : Brazil.
- epidemiology : HIV Seropositivity.
- genetics : Genes, pol, HIV-1.
- transmission : HIV Seropositivity.
- virology : HIV Seropositivity.
- Adult, Base Sequence, Cluster Analysis, Female, Genetic Variation, Genotype, Humans, Male, Molecular Sequence Data, Phylogeny, Prevalence, Recombination, Genetic, Sentinel Surveillance.
Abstract
HIV-1 CRF02_AG is the most prevalent intersubtype recombinant form worldwide. Six HIV-1 samples from patients living in Rio de Janeiro, Brazil, were subtyped as CRF02_AG at the pol gene between 2004 and 2011. To trace the origin of these viruses, they were compared with 793 CRF02_AG pol sequences of African origin and another four Brazilian CRF02_AG pol sequences previously described. Phylogenetic analysis reveals that there have been at least four introductions of the CRF02_AG clade in Brazil, as signified by the presence of four phylogenetically distinct lineages, probably originated from western African countries (Benin, Ghana, and Guinea-Bissau). At least two CRF02_AG Brazilian lineages were successful in getting established and disseminated throughout the Rio de Janeiro state, with evidence of both horizontal and vertical transmission. Continuous epidemiological surveillance of HIV-1 strains circulating in Brazil is of paramount importance to the early detection of newly emerging viral lineages.
DOI: 10.1089/AID.2011.0381
PubMed: 22333001
Affiliations:
Links toward previous steps (curation, corpus...)
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- to stream Ncbi, to step Merge: 000472
- to stream Ncbi, to step Curation: 000472
- to stream Ncbi, to step Checkpoint: 000472
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- to stream Main, to step Curation: 000728
Le document en format XML
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Eyer-Silva</name></author><author><name sortKey="Chequer Fernandez, Saada L" sort="Chequer Fernandez, Saada L" uniqKey="Chequer Fernandez S" first="Saada L" last="Chequer-Fernandez">Saada L. Chequer-Fernandez</name></author><author><name sortKey="Morgado, Mariza G" sort="Morgado, Mariza G" uniqKey="Morgado M" first="Mariza G" last="Morgado">Mariza G. Morgado</name></author><author><name sortKey="Couto Fernandez, Jose Carlos" sort="Couto Fernandez, Jose Carlos" uniqKey="Couto Fernandez J" first="José Carlos" last="Couto-Fernandez">José Carlos Couto-Fernandez</name></author></analytic><series><title level="j">AIDS research and human retroviruses</title><idno type="eISSN">1931-8405</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Base Sequence</term><term>Brazil (epidemiology)</term><term>Cluster Analysis</term><term>DNA, Viral (genetics)</term><term>Female</term><term>Genes, pol (genetics)</term><term>Genetic Variation</term><term>Genotype</term><term>HIV Seropositivity (epidemiology)</term><term>HIV Seropositivity (transmission)</term><term>HIV Seropositivity (virology)</term><term>HIV-1 (genetics)</term><term>Humans</term><term>Male</term><term>Molecular Sequence Data</term><term>Phylogeny</term><term>Prevalence</term><term>Recombination, Genetic</term><term>Sentinel Surveillance</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ADN viral (génétique)</term><term>Adulte</term><term>Analyse de regroupements</term><term>Brésil (épidémiologie)</term><term>Données de séquences moléculaires</term><term>Femelle</term><term>Gènes pol (génétique)</term><term>Génotype</term><term>Humains</term><term>Mâle</term><term>Phylogénie</term><term>Prévalence</term><term>Recombinaison génétique</term><term>Surveillance sentinelle</term><term>Séquence nucléotidique</term><term>Séropositivité VIH (transmission)</term><term>Séropositivité VIH (virologie)</term><term>Séropositivité VIH (épidémiologie)</term><term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (génétique)</term><term>Variation génétique</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>DNA, Viral</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Brazil</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>HIV Seropositivity</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Genes, pol</term><term>HIV-1</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ADN viral</term><term>Gènes pol</term><term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1)</term></keywords><keywords scheme="MESH" qualifier="transmission" xml:lang="en"><term>HIV Seropositivity</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Séropositivité VIH</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>HIV Seropositivity</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Brésil</term><term>Séropositivité VIH</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Base Sequence</term><term>Cluster Analysis</term><term>Female</term><term>Genetic Variation</term><term>Genotype</term><term>Humans</term><term>Male</term><term>Molecular Sequence Data</term><term>Phylogeny</term><term>Prevalence</term><term>Recombination, Genetic</term><term>Sentinel Surveillance</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Analyse de regroupements</term><term>Données de séquences moléculaires</term><term>Femelle</term><term>Génotype</term><term>Humains</term><term>Mâle</term><term>Phylogénie</term><term>Prévalence</term><term>Recombinaison génétique</term><term>Surveillance sentinelle</term><term>Séquence nucléotidique</term><term>Variation génétique</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Brésil</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">HIV-1 CRF02_AG is the most prevalent intersubtype recombinant form worldwide. Six HIV-1 samples from patients living in Rio de Janeiro, Brazil, were subtyped as CRF02_AG at the pol gene between 2004 and 2011. To trace the origin of these viruses, they were compared with 793 CRF02_AG pol sequences of African origin and another four Brazilian CRF02_AG pol sequences previously described. Phylogenetic analysis reveals that there have been at least four introductions of the CRF02_AG clade in Brazil, as signified by the presence of four phylogenetically distinct lineages, probably originated from western African countries (Benin, Ghana, and Guinea-Bissau). At least two CRF02_AG Brazilian lineages were successful in getting established and disseminated throughout the Rio de Janeiro state, with evidence of both horizontal and vertical transmission. Continuous epidemiological surveillance of HIV-1 strains circulating in Brazil is of paramount importance to the early detection of newly emerging viral lineages.</div></front></TEI><affiliations><list><country><li>Brésil</li></country><region><li>État de Rio de Janeiro</li></region><settlement><li>Rio de Janeiro</li></settlement></list><tree><noCountry><name sortKey="Bello, Gonzalo" sort="Bello, Gonzalo" uniqKey="Bello G" first="Gonzalo" last="Bello">Gonzalo Bello</name><name sortKey="Chequer Fernandez, Saada L" sort="Chequer Fernandez, Saada L" uniqKey="Chequer Fernandez S" first="Saada L" last="Chequer-Fernandez">Saada L. Chequer-Fernandez</name><name sortKey="Couto Fernandez, Jose Carlos" sort="Couto Fernandez, Jose Carlos" uniqKey="Couto Fernandez J" first="José Carlos" last="Couto-Fernandez">José Carlos Couto-Fernandez</name><name sortKey="Eyer Silva, Walter A" sort="Eyer Silva, Walter A" uniqKey="Eyer Silva W" first="Walter A" last="Eyer-Silva">Walter A. Eyer-Silva</name><name sortKey="Morgado, Mariza G" sort="Morgado, Mariza G" uniqKey="Morgado M" first="Mariza G" last="Morgado">Mariza G. Morgado</name></noCountry><country name="Brésil"><region name="État de Rio de Janeiro"><name sortKey="Delatorre, Edson Oliveira" sort="Delatorre, Edson Oliveira" uniqKey="Delatorre E" first="Edson Oliveira" last="Delatorre">Edson Oliveira Delatorre</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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